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首頁 /科研細(xì)胞 /鼠源細(xì)胞系 /其他鼠源細(xì)胞系 /EOMA(小鼠血管內(nèi)皮瘤細(xì)胞)

EOMA(小鼠血管內(nèi)皮瘤細(xì)胞)

CBP61138

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I. General information 
Synonyms: EOMA
Background: The EOMA cell line was originally derived in 1980 from a mixed hemangioendothelioma arising in an adult mouse.
Species: Mus musculus, mouse
Tissue: tumor
Disease: hemangioendothelioma
Gender: adult
Morphology: endothelial
Growth Mode: adherent
Doubling Time: N/A
DNA Profile: N/A
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Culture Medium:

DMEM+10%FBS

EOMA完全培養(yǎng)基,# CBP61138M
We strongly suggest to purchase the complete medium from us.

Cryopreservation medium: 90%FBS+10%DMSO
Antigen Expression: CD31 +
vascular addressin +
CD45 (Ly5-T200) +
Receptor Expression: acetylated low density liproprotein
Ref
Oncogene: N/A
Genes Expressed: angiotensin converting enzyme (ACE)
thrombospondin
cathepsin L
endostatin
interleukin-6 (interleukin 6, IL-6)
Cellular Products: angiotensin converting enzyme (ACE)
thrombospondin
cathepsin L
endostatin
interleukin-6 (interleukin 6, IL-6)
Tumor Formation: Yes, in syngeneic mice
Comments: The cells synthesize angiotensin-converting enzyme, express surface receptors for acetylated low density lipoprotein, produce thrombospondin and show intracellular staining with an antibody to von Willebrand factor.
Cathepsin L is secreted by EOMA cells and is responsible for the generation of endostatin L.
Although constitutive cytokine gene expression exists in EOMA cells, the level of IL-6 mRNA is prominently elevated by incubation with Liposome encapsulated hemoglobin (LEH).
The cells constitutively express the vascular addressin identified by antibody MECA-99.
EOMA cells exhibit characteristic endothelial cell properties, such as rearrangement into tubelike structures on Matrigel and retention of cobblestone morphology at confluence. They behave in vitro in a manner similar to microvascular endothelial cells.
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